Calcium and thiol reactivity of human plasma clotting factor XIII
نویسندگان
چکیده
منابع مشابه
Latex agglutination-inhibition test for screening blood-clotting factor XIII in human plasma.
For the assay of blood-clotting Factor XIII (Fibrin-Stabilizing Factor, FSF), the antibody-neutralization test (Bohn and Haupt, 1968), the monodancylcadaverine incorporation test (Lorand et al., 1969; Nishimura et al., 1975) and the Laurell method are tried in our country (Hidano et al., 1975). None of them, however, could be applied to the clinical screening for Factor XIII-deficient cases; th...
متن کاملFactor XIII in human plasma and platelets.
Plasma and platelet factor XIII levels were measured in normal human donors and in a patient congenitally deficient in factor XIII. The purpose of these experiments was to study the role of platelet factor XIII in blood coagulation. On polyacrylamide disc electrophoresis, factor XIII activity in extracts of washed normal platelets appeared as a single peak. This peak was missing or very low whe...
متن کاملClotting factor XIII and desmopressin improve hemostasis in uncontrolled bleeding.
PURPOSE To investigate hemostatic effects of supplementary factor XIII and desmopressin (DDAVP) in resuscitation of uncontrolled bleeding. METHODS Fifty-four rabbits were randomized in nine groups: G1: Sham; G2: FXIII and normotensive resuscitation (NBP); G3: FXIII and permissive hypotension (PH) (MAP 60% baseline); G4: FXIII/DDAVP/NBP; G5: FXIII/DDAVP/PH; G6: NBP only; G7: FXIII no hemorrhag...
متن کاملMeasurement of factor XIII activity in plasma.
Coagulation factor XIII (FXIII) is converted by thrombin and Ca(2+) into an active transglutaminase (FXIIIa) in the final phase of coagulation cascade. Its main function is the mechanical stabilization of fibrin clot and its protection from fibrinolysis by cross-linking of fibrin chains and α(2)-plasmin inhibitor to fibrin. In non-substituted patients FXIII deficiency is a severe hemorrhagic di...
متن کاملStructural features of glutamine substrates for human plasma factor XIIIa (activated blood coagulation factor XIII).
The action of human plasma factor XIIIa (thrombin-activated blood coagulation factor XIII) and guinea pig liver transglutaminase on purified caseins, fibrin, the derivatized gamma chain of fibrin, and a number of synthetic glutamine peptides, and peptide derivatives is reported. There are wide variations in the properties of the individual proteins and peptides as substrates for amine incorpora...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1974
ISSN: 0264-6021
DOI: 10.1042/bj1410675